GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12908161 | 1 | rs56864281 | chr15:85357649 | LOC388152 | chr15:84867600-84898920:- | -0.47 | -7.81 | 3.69E-14 | Schizophrenia |
| THCA | cis | rs12908161 | 1 | rs56864281 | chr15:85357649 | NMB | chr15:85198362-85201802:- | 0.37 | 7.8 | 3.92E-14 | Schizophrenia |
| THCA | cis | rs4925540 | 1 | rs56884994 | chr1:247211057 | OR2T8 | chr1:248084320-248085256:+ | -0.19 | -3.64 | 0.000299 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs56884994 | chr1:247211057 | OR2W3 | chr1:248031265-248060142:+ | -0.17 | -3.34 | 0.000889 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs7818688 | 1 | rs56901035 | chr8:96043188 | C8orf38 | chr8:95908040-96088396:+ | -0.26 | -4.56 | 6.5E-6 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs2084898 | 1 | rs569044 | chr11:119999191 | TRIM29 | chr11:119981995-120008863:- | -0.39 | -5.77 | 1.44E-8 | Stroke (pediatric) |
| THCA | cis | rs2129782 | 1 | rs56912549 | chr8:89365835 | MMP16 | chr8:89049462-89339717:- | 0.31 | 4.88 | 1.48E-6 | Electrodermal activity |
| THCA | cis | rs569214 | 1 | rs569214 | chr8:27487790 | PNOC | chr8:28174649-28200866:+ | -0.13 | -3.75 | 0.000199 | Alzheimer's disease |
| THCA | cis | rs8078723 | 1 | rs56922390 | chr17:38157021 | GSDMA | chr17:38119226-38134019:+ | -0.32 | -7.28 | 1.39E-12 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs477692 | 1 | rs569235 | chr10:131411620 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.44 | 5.83E-27 | Response to temozolomide |
| THCA | cis | rs12748152 | 1 | rs56932185 | chr1:27056643 | ZDHHC18 | chr1:27153201-27182207:+ | 0.8 | 8.6 | 1.15E-16 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs17657012 | 1 | rs56945350 | chr14:55176082 | SAMD4A | chr14:55034637-55260033:+ | -0.4 | -4.44 | 1.11E-5 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs4730250 | 1 | rs56949084 | chr7:107157387 | DLD | chr7:107531586-107561642:+ | 0.14 | 3.43 | 0.000644 | Osteoarthritis |
| THCA | cis | rs6041 | 1 | rs569557 | chr13:113769917 | F7 | chr13:113760105-113774994:+ | -0.27 | -3.91 | 0.000106 | End-stage coagulation |
| THCA | cis | rs515910 | 1 | rs569856 | chr10:105942304 | C10orf79 | chr10:105889647-105992120:- | 0.25 | 8.09 | 4.8E-15 | Attention deficit hyperactivity disorder |